Do Lubricants Affect Pregnancy Chances? Many couples wonder if lubricants can prevent conception. Oil based lubricants (like Vaseline, coconut oil, creams, lotions) can slow down sperm movement and reduce pregnancy chances. Do lubricants affect male fertility and sperm quality? Let's talk about lubricants and fertility. If you're TTC, the type of lube you use can either support or sabotage your chances of conceiving. Here's what research shows: All impact sperm in Let's talk about lubricants and fertility. If you're TTC, the type of lube you use can either support or sabotage your chances of conceiving. Here's what research shows: All impact sperm in